Cisplatin macrophage

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August undefined, 2024

WebMar 20, 2024 · This study was designed to investigate whether the oral administration of M.C could decrease cisplatin-induced sarcopenia by modulating M2 macrophage polarization in mice. C57BL/6 mice were injected intraperitoneally with cisplatin (2.5 mg/kg) to mimic chemotherapy-induced sarcopenia. WebNov 1, 2014 · Cisplatin, a member of platinum agents, is one of the most widely used anticancer chemical drugs and a part of the treatment to many types of solid tumors, including head and neck, breast, testicular, ovarian, cervical, lung, and colorectal cancers (Rabik & Dolan, 2007 ).

Low-dose cisplatin administration to septic mice improves …

WebJan 24, 2024 · The results suggested that SQFZ could inhibit MDA-MB-231/DDP cell growth related to M2 macrophages. When cisplatin was used in combination with SQFZ 40 … WebCisplatin decreases mitochondrial function in sensory axons, and HDAC6 inhibition can promote axonal transport of healthy mitochondria. Indeed, the HDAC6 inhibitor normalized cisplatin-induced tibial nerve mitochondrial deficits. However, this was independent of macrophages and IL-10 signaling. granna sherlock

Inhibition of mycobacteria proliferation in macrophages …

WebJan 24, 2024 · When cisplatin was used in combination with SQFZ 40 μl/mL, the survival in the cisplatin 60 μM and 120 μM groups reduced by 50.8% and 72.5%, respectively, in the co-cultured MDA-MB-231/DDP cells and M2 macrophages . These results suggested that SQFZ improved the sensitivity of cisplatin through M2 macrophages. WebHere, we show that targeting tumour-associated macrophages by colony-stimulating factor-1 receptor (CSF-1R) blockade in the K14cre;Cdh1 F/F ;Trp53 F/F transgenic mouse model for breast cancer stimulates intratumoural type I interferon (IFN) signalling, which enhances the anticancer efficacy of platinum-based chemotherapeutics. WebFeb 7, 2024 · In the present study, we investigated the effects of magnolol on muscle wasting and macrophage subtypes in a cisplatin-induced sarcopenia mouse model. We showed that magnolol significantly attenuated the body weight and the muscle loss induced by cisplatin injection. chinook lumber north bend

Low-dose cisplatin administration to septic mice improves …

Magnoliae Cortex Alleviates Muscle Wasting by Modulating M2 Macrophages …

WebJun 6, 2024 · Herein, a potent strategy to construct a macrophage-mediated drug delivery platform loaded with a nanosphere (CpG-ASO-Pt) (CAP) composed of functional nucleic … WebJul 1, 2013 · Cisplatin is widely used to treat cancer, and one of its limiting side effects is acute kidney injury characterized by acute tubular necrosis … grannhornWebOct 18, 2016 · Macrophages are the main component of inflammatory cells, and macrophages that infiltrate into the tumour microenvironment are referred to as tumour-associated macrophages (TAMs). ... Pirfenidone was recently reported to induce apoptosis of CAFs and to increase the anti-tumour effect of cisplatin in a murine model; however, … chinook mall bedding store

"WebM2 macrophage polarization modulates epithelial-mesenchymal transition in cisplatin-induced tubulointerstitial fibrosis Biomedicine (Taipei). 2016 Mar;6 (1):5. doi: 10.7603/s40681-016-0005-5. Epub 2016 Feb 10. Authors Chia-Cherng Yu 1 2 , Chiang-Ting Chien 3 , Tzu-Ching Chang 4 5 Affiliations " - Cisplatin macrophage

Cisplatin macrophage

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WebApr 13, 2024 · Background. Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the … WebMar 18, 2024 · Salvagno et al. 4 found that neutrophils, but not macrophages, limit tumour response to cisplatin by suppressing CD8 + …

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WebApr 13, 2024 · Background: Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates that tumor-associated macrophages (TAMs) play an important role in chemoresistance of cancer. WebMar 8, 2024 · Our data indicated that cell damage induced by cisplatin activated TIM3 on CD8+ T cells, leading to increased IL-13 production, which in turn induced macrophage IL-10 production and resolution of CIPN. Development of exogenous activators of the IL-13/IL-10 pain resolution pathway may provide a way to treat the underlying cause of chronic pain.

WebSep 13, 2024 · Our findings in cisplatin-induced injury underscore the value of dissecting the functions of individual MP subsets in kidney disease, which may enable therapeutic targeting of specific immune components in the absence of general immunosuppression. Sign up for PNAS alerts. Get alerts for new articles, or get an alert when an article is cited. WebApr 11, 2024 · 2024年查处的不端行为案件处理结果通报（第一批次）. 近期，经国家自然科学基金委员会监督委员会调查审议、国家自然科学基金委员会委务会议审定，国家自然科学基金委员会对相关科研不端案件涉事主体进行了处理。. 现将给予通报批评的有关案情及处理 ...

WebApr 11, 2024 · Sorafenib induces macrophage pyroptosis, ... The chemotherapy drug cisplatin (DDP) combined with low-dose BI2536, a polo-like Kinase 1(PLK1) inhibitor, can increase chemosensitivity by inducing ... WebAug 24, 2024 · 1. Introduction. Cisplatin (CDDP), a platinum-based anticancer agent, is one of the most commonly used chemotherapy drugs in the treatment of patients with various types of cancer, such as bladder, ovarian, head and neck, lung, testicular, cervical, esophageal, and breast cancer [].CDDP and its analogs, carboplatin and oxaliplatin, …

WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. Ubiquitin-specific protease (USP14) is involved in various pathological conditions ...

WebDec 2, 2024 · The use of resveratrol with cisplatin inhibited suppressed tumor growth when compared with cisplatin alone. Conclusion This study revealed that resveratrol inhibited breast cancer cell proliferation by promoting M1/M2 macrophage polarization ratio and suppressing IL-6/pSTAT3 pathway. Introduction granna\\u0027s beach house emerald isle ncWebCisplatin does not affect the phenotype of CAMs, or the anti-tumor and chemo-sensitivity effects of CAMs on ovarian cancer cells. (A) mRNA expression of macrophage polarization markers as... chinook mall calgary apple storeWebApr 14, 2024 · Other lines of research have revealed a relationship between HAT-1 and hepatocellular carcinoma (HCC) treatment with cisplatin, which is commonly associated with drug resistance in patients with this cancer . Notably, ... As a monocyte- and macrophage-specific scavenger receptor (CD163) that is shed into plasma, soluble … chinook mall canadaWebNov 30, 2024 · For the first time, in vitro studies on cisplatin exposure addressed human monocytes and monocyte-derived macrophages (undifferentiated THP-1 monocytic … grannicks police supplyWebMacrophage Stimulating Protein May Promote Tubular Regeneration after Acute Injury . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with and we'll email you a reset link. ... grannick\u0027s bitter apple for dogs spray bottleWebIn IL-4-activated macrophages (M2 macrophages), the Krebs cycle and oxidative phosphorylation are intact and fatty acid oxidation (FAO) is also utilized. These metabolic alterations in response to the nature of the stimulus are proving to be determinants of the effector functions of M1 and M2 macrophages. chinook mall calgary hoursWebNational Center for Biotechnology Information chinook mall directory map