WitrynaNational Center for Biotechnology Information Witryna16 gru 2005 · Alternatively, it may be that there is an increased risk of an imprinting disorder following ART because of an association with infertility per se rather than …
Imprinting disorders and assisted reproductive technology
Witryna7 cze 2003 · ARTs now account for between 1% and 3% of annual births in many western countries and in-vitro fertilisation (IVF) services are growing worldwide. In general, the incidence of abnormalities at birth is reassuringly low and children develop normally. ... high for such a rare congenital condition and such findings are … Imprinting disorders are caused by genetic defects or epigenetic mutations (DNA methylation); i.e., aberrant DNA methylation of differentially methylated regions (DMRs) that regulate allele-specific expression of imprinted genes . The relationship between ART and aberrant genomic imprinting is … Zobacz więcej We conducted a Japanese nationwide epidemiological study of four imprinting disorders to determine associations with ART. We contacted a total of 2777 pediatric departments of all hospitals that were identified … Zobacz więcej To investigate whether disease phenotypes in patients could be altered by ART, we compared the clinical features in detail. There were no major differences overall between … Zobacz więcej We annotated genomic regions and then identified the DNA methylation variation (DMVs) showing absolute methylation changes ≥ 7.5% and statistically significant differences (false discovery rate (FDR) < 0.05) in the ART … Zobacz więcej To investigate the genome-wide DNA methylation changes in ART-SRS patients, we performed reduced representation bisulfite sequencing (RRBS) to produce DNA … Zobacz więcej cst error while writing mesh fill domain file
Assisted reproductive therapies and imprinting disorders—a …
Witryna1 lut 2014 · Imprinting disorders and IVF/ICSI Epigenetic mechanisms and imprinting. Recent studies suggest a link between IVF/ICSI and epigenetic modifications, which can be defined as phenotypic or gene expression changes (Berger et al., 2009). Examples of epigenetic changes include DNA methylation, histone modification and other chemical … Witryna19 cze 2014 · Congenital imprinting disorders [BWS, AS, PWS (Prader–Willi syndrome; NIM176270) and SRS (Silver–Russell syndrome; NIM180860)] are rare diseases. It is known that they are caused by uniparental disomy (UPD), duplications, gene mutation (deletion), and aberrant DNA methylation in a specific region (Fig. 2 ). Witryna1 mar 2013 · There are reports that in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) is associated with imprinting disorders, and it is even presumed that … early geneticists thought that