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Witryna1 maj 2006 · In the presence of appropriate doses and normal renal function, metformin-induced acute pancreatitis was never reported. However, when glomerular filtration rate (GFR) is <60 ml/min, metformin accumulates and adverse effects, mainly lactic acidosis, may occur ( 5, 2 ). Witryna1 maj 2006 · In the presence of appropriate doses and normal renal function, metformin-induced acute pancreatitis was never reported. However, when glomerular filtration … Witryna15 lip 2024 · The FDA has announced that 14 companies have voluntarily recalled their extended release metformin due to the possibility that it includes unsafe levels of NDMA, a toxic substance. Editor's note: This article was first published on July 15, 2024 and has since been updated to reflect the latest recalls. penner whirlpool